Introduction:
Ducati has long been a dominant force in the superbike segment, and the latest iteration of the Panigale V4 is no exception. For 2025, the Italian manufacturer has introduced two distinct variants: the standard Panigale V4 and the high-performance Panigale V4 S.
While both motorcycles share the same aggressive styling and MotoGP-derived technology, there are crucial differences that set them apart. If you’re torn between these two superbikes, this guide will help you understand their key distinctions.
1. Suspension: Standard vs. Electronic Adjustability:
One of the biggest differences between the two variants is the suspension system. The standard Panigale V4 comes with fully adjustable 43mm Showa forks at the front and a Sachs monoshock at the rear.
Meanwhile, the Panigale V4 S takes things a step further with an electronically adjustable Ohlins Smart EC 2.0 suspension, allowing riders to fine-tune their setup for different riding conditions at the push of a button. This makes the V4 S more adaptable to both track and street riding.
2. Wheels: Forged Aluminum for Enhanced Performance
The Panigale V4 S gets a significant upgrade in terms of wheels. Unlike the standard V4’s light alloy wheels, the V4 S is equipped with forged aluminum alloy wheels, which are not only stronger but also reduce unsprung weight.

This results in improved handling, better acceleration, and a more agile riding experience. Additionally, the V4 S weighs 4 kg (8.8 lbs) less than the standard model, enhancing its power-to-weight ratio.
3. Battery: Standard vs. Lightweight Lithium-Ion:
Another weight-saving measure on the Panigale V4 S is the inclusion of a lithium-ion battery instead of the standard lead-acid battery found on the regular Panigale V4. This contributes to the S model’s overall reduced weight, making it even more performance-focused.
4. Cosmetic Differences: Premium Finishes on the V4 S:
While both variants share the same aggressive bodywork and aerodynamic design, there are minor cosmetic differences. The Panigale V4 features a red-painted front fender, whereas the V4 S gets a matte gray finish. Additionally, the V4 S has a gold-colored Ohlins front fork, further distinguishing it from the base model. The wheel designs also differ, reinforcing the premium nature of the S variant.

5. Price: Is the V4 S Worth the Extra Cost?
When it comes to pricing, the standard Panigale V4 is more affordable, starting at around $23,295 (MSRP, U.S.), while the Panigale V4 S comes in at a higher price point of $29,995 (MSRP, U.S.). The additional cost of the V4 S accounts for its superior suspension, lightweight wheels, and premium finishes. If you’re a track-day enthusiast looking for the best performance, the V4 S is well worth the investment. However, if you’re looking for a superbike that offers exceptional performance without breaking the bank, the standard V4 is still a fantastic option.
Final Verdict: Which One Should You Choose?
Both the Ducati Panigale V4 and Panigale V4 S are exceptional motorcycles that deliver exhilarating performance. The choice comes down to your preferences and riding needs. If you prioritize top-tier suspension, lightweight components, and track-ready performance, the V4 S is the better choice. On the other hand, if you want a superbike with outstanding performance at a lower price point, the standard Panigale V4 won’t disappoint.
No matter which model you choose, Ducati’s engineering excellence ensures that both variants deliver an unmatched riding experience. Whether you’re tearing up the racetrack or cruising down scenic roads, the Panigale V4 series continues to be the gold standard in the world of superbikes.